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1

From discoveries in ageing research to therapeutics for healthy ageing

Campisi, Judith, Kapahi, Pankaj, Lithgow, Gordon J., Melov, Simon, Newman, John C., Verdin, Eric

Journal:

Year:

2019

Language:

english

File:

PDF, 1.32 MB

english, 2019

2

Medical research: Treat ageing

Fontana, Luigi, Kennedy, Brian K., Longo, Valter D., Seals, Douglas, Melov, Simon

Journal:

Year:

2014

Language:

english

File:

PDF, 1.38 MB

english, 2014

3

Different Oxidative Stress Response in Keratinocytes and Fibroblasts of Reconstructed Skin Exposed to Non Extreme Daily-Ultraviolet Radiation

Marionnet, Claire, Pierrard, Cécile, Lejeune, François, Sok, Juliette, Thomas, Marie, Bernerd, Françoise, Melov, Simon

Journal:

Year:

2010

Language:

english

File:

PDF, 3.05 MB

english, 2010

4

From discoveries in ageing research to therapeutics for healthy ageing

Campisi, Judith, Kapahi, Pankaj, Lithgow, Gordon J., Melov, Simon, Newman, John C., Verdin, Eric

Journal:

Year:

2019

File:

PDF, 1.32 MB

2019

5

Age-related behaviors have distinct transcriptional profiles in Caenorhabditis elegans

Tamara R. Golden, Alan Hubbard, Caroline Dando, Michael A. Herren, Simon Melov

Journal:

Year:

2008

Language:

english

File:

PDF, 632 KB

english, 2008

6

Microarray analysis of gene expression with age in individual nematodes

Tamara R. Golden, Simon Melov

Journal:

Year:

2004

Language:

english

File:

PDF, 435 KB

english, 2004

7

Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function: Implications for Parkinson’s disease

Almas Siddiqui, Shankar J. Chinta, Jyothi K. Mallajosyula, Subramanian Rajagopolan, Ingrid Hanson, Anand Rane, Simon Melov, Julie K. Andersen

Journal:

Free Radical Biology and Medicine

Year:

2012

Language:

english

File:

PDF, 1.38 MB

english, 2012

8

Gene expression profiling in mitochondrial disease: assessment of microarray accuracy by high-throughput Q-PCR

Kenneth B. Beckman, Kathleen Y. Lee, Tamara Golden, Simon Melov

Journal:

Year:

2004

Language:

english

File:

PDF, 539 KB

english, 2004

9

81 Differential gene expression response to point mutations, A3243G and A3260G, in mitochondrial DNA of human skeletal muscle

Sandeep Raha, Simon Melov, Adeel Safdar, Heathcliff D’Sa, Brian H. Robinson, Mark A. Tarnopolsky

Journal:

Year:

2007

Language:

english

File:

PDF, 58 KB

english, 2007

10

Endurance exercise reduces mitochondrial DNA random point mutations and reverses the premature aging transcriptome in PolG mutator mouse: I believe in miracle!

Adeel Safdar⁎, Simon Melov, Mahmood Akhtar, Gregory C. Kujoth, Tomas A. Prolla, Bart P. Hettinga, Mark A. Tarnopolsky

Journal:

Year:

2011

Language:

english

File:

PDF, 74 KB

english, 2011

11

Free radicals and antioxidants in otolaryngology

Michael Seidman, Simon Melov, John Althaus, Russell Reiter, Jochen Schacht, Michael Angel

Journal:

Otolaryngology - Head and Neck Surgery

Year:

1996

Language:

english

File:

PDF, 70 KB

english, 1996

12

Thermotolerance and Extended Life-Span Conferred by Single-Gene Mutations and Induced by Thermal Stress

Gordon J. Lithgow, Tiffany M. White, Simon Melov and Thomas E. Johnson

Journal:

Proceedings of the National Academy of Sciences

Year:

1995

Language:

english

File:

PDF, 1.01 MB

english, 1995

13

Ribosomal Proteins Rpl22 and Rpl22l1 Control Morphogenesis by Regulating Pre-mRNA Splicing

Zhang, Yong, O’Leary, Monique N., Peri, Suraj, Wang, Minshi, Zha, Jikun, Melov, Simon, Kappes, Dietmar J., Feng, Qing, Rhodes, Jennifer, Amieux, Paul S., Morris, David R., Kennedy, Brian K., Wiest, Da

Journal:

Year:

2017

Language:

english

File:

PDF, 3.44 MB

english, 2017

14

Resistance Exercise Reverses Aging in Human Skeletal Muscle

Melov, Simon, Tarnopolsky, Mark A., Beckman, Kenneth, Felkey, Krysta, Hubbard, Alan, Wenner, Peter

Journal:

Year:

2007

Language:

english

File:

PDF, 273 KB

english, 2007

15

Microscale fractionation facilitates detection of differentially expressed proteins in Alzheimer's disease brain samples

Mary F. Lopez, Alvydas Mikulskis, Eva Golenko, Simon Melov, David Bennett, Alex Cherkasskiy, Scott Kuzdzal, Susan Kramer, Dan Sissors

Journal:

ELECTROPHORESIS

Year:

2004

Language:

english

File:

PDF, 318 KB

english, 2004

16

Microscale fractionation facilitates detection of differentially expressed proteins in Alzheimer's disease brain samples (vol. 25, Issue 15, pp. 2557-2563)

Mary F. Lopez, Alvydas Mikulskis, Eva Golenko, Simon Melov, David Bennett, Alex Cherkasskiy, Scott Kuzdzal, Susan Kramer, Dan Sissors

Journal:

ELECTROPHORESIS

Year:

2004

Language:

english

File:

PDF, 18 KB

english, 2004

17

Endogenous mitochondrial oxidative stress: neurodegeneration, proteomic analysis, specific respiratory chain defects, and efficacious antioxidant therapy in superoxide dismutase 2 null mice

Douglas Hinerfeld, Mathew D. Traini, Ron P. Weinberger, Bruce Cochran, Susan R. Doctrow, Jenny Harry, Simon Melov

Journal:

Journal of Neurochemistry

Year:

2004

Language:

english

File:

PDF, 276 KB

english, 2004

18

Editorial

Tim Cowen, Marc Tatar, Simon Melov

Journal:

Year:

2002

Language:

english

File:

PDF, 53 KB

english, 2002

19

Oxidative stress and aging: beyond correlation

Tamara R. Golden, Douglas A. Hinerfeld, Simon Melov

Journal:

Year:

2002

Language:

english

File:

PDF, 170 KB

english, 2002

20

Introduction

Simon Melov, Gordon Lithgow

Journal:

Year:

2006

Language:

english

File:

PDF, 28 KB

english, 2006

21

Dramatic age-related changes in nuclear and genome copy number in the nematode Caenorhabditis elegans

Tamara R. Golden, Kenneth B. Beckman, Andreia H. J. Lee, Nancy Dudek, Alan Hubbard, Enrique Samper, Simon Melov

Journal:

Year:

2007

Language:

english

File:

PDF, 266 KB

english, 2007

22

Loss of intestinal nuclei and intestinal integrity in aging C. elegans

Matthew D. McGee, Darren Weber, Nicholas Day, Cathy Vitelli, Danielle Crippen, Laura A. Herndon, David H. Hall, Simon Melov

Journal:

Year:

2011

Language:

english

File:

PDF, 867 KB

english, 2011

23

Special Issue: Mitochondria and Aging – Facts and Fancies

David Nicholls, Simon Melov

Journal:

Year:

2004

Language:

english

File:

PDF, 24 KB

english, 2004

24

Introduction

Journal:

Year:

2004

Language:

english

File:

PDF, 27 KB

english, 2004

25

Introduction

Journal:

Year:

2004

Language:

english

File:

PDF, 30 KB

english, 2004

26

Mitochondrial Oxidative Stress: Physiologic Consequences and Potential for a Role in Aging

Journal:

Annals of the New York Academy of Sciences

Year:

2000

Language:

english

File:

PDF, 214 KB

english, 2000

27

Therapeutics against Mitochondrial Oxidative Stress in Animal Models of Aging

Journal:

Annals of the New York Academy of Sciences

Year:

2002

Language:

english

File:

PDF, 58 KB

english, 2002

28

10.1038/448

Wallace, Douglas C., Melov, Simon

Journal:

Nature Genetics

Year:

1998

Language:

english

File:

PDF, 56 KB

english, 1998

29

Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts

Parrinello, Simona, Samper, Enrique, Krtolica, Ana, Goldstein, Joshua, Melov, Simon, Campisi, Judith

Journal:

Nature Cell Biology

Year:

2003

Language:

english

File:

PDF, 740 KB

english, 2003

30

A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase

Melov, Simon, Schneider, Julie A., Day, Brian J., Hinerfeld, Douglas, Coskun, Pinar, Mirra, Suzanne S., Crapo, James D., Wallace, Douglas C.

Journal:

Nature Genetics

Year:

1998

File:

PDF, 980 KB

1998

31

Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase

Li, Yibing, Huang, Ting-Ting, Carlson, Elaine J., Melov, Simon, Ursell, Philip C., Olson, Jean L., Noble, Linda J., Yoshimura, Midori P., Berger, Christoph, Chan, Pak H.

Journal:

Nature Genetics

Year:

1995

File:

PDF, 1007 KB

1995

32

Mitochondrial biology, degenerative diseases and aging

Douglas C. Wallace, Michael D. Brown, Simon Melov, Brett Graham, Marie Lott

Journal:

Year:

1998

Language:

english

File:

PDF, 51 KB

english, 1998

33

Hyperplasia, reduced E-cadherin expression, and developmental arrest in mammary glands oxidatively stressed by loss of mitochondrial superoxide dismutase

Hema Parmar, Simon Melov, Enrique Samper, Britt-Marie Ljung, Gerald R. Cunha, Christopher C. Benz

Journal:

Year:

2005

Language:

english

File:

PDF, 666 KB

english, 2005

34

On the Programmed/Non-Programmed Nature of Ageing within the Life History

Thomas B.L. Kirkwood, Simon Melov

Journal:

Current Biology

Year:

2011

Language:

english

File:

PDF, 153 KB

english, 2011

35

The garlic constituent diallyl trisulfide increases the lifespan of C. elegans via skn-1 activation

Anna A. Powolny, Shivendra V. Singh, Simon Melov, Alan Hubbard, Alfred L. Fisher

Journal:

Experimental Gerontology

Year:

2011

Language:

english

File:

PDF, 930 KB

english, 2011

36

Mice transgenic for Alzheimer disease β-amyloid develop lens cataracts that are rescued by antioxidant treatment

Simon Melov, Norman Wolf, Dorothea Strozyk, Susan R. Doctrow, Ashley I. Bush

Journal:

Free Radical Biology and Medicine

Year:

2005

Language:

english

File:

PDF, 113 KB

english, 2005

37

Pharmacogenomic profiling of an oxidative stress-mediated spongiform encephalopathy

Tamara R. Golden, Alan Hubbard, Karl J. Morten, Doug Hinerfeld, Simon Melov

Journal:

Free Radical Biology and Medicine

Year:

2005

Language:

english

File:

PDF, 639 KB

english, 2005

38

Increase in mitochondrial biogenesis, oxidative stress, and glycolysis in murine lymphomas

Enrique Samper, Lucia Morgado, Juan C. Estrada, Antonio Bernad, Alan Hubbard, Susana Cadenas, Simon Melov

Journal:

Free Radical Biology and Medicine

Year:

2009

Language:

english

File:

PDF, 587 KB

english, 2009

39

Impaired spare respiratory capacity in cortical synaptosomes from Sod2 null mice

James M. Flynn, Sung W. Choi, Nicholas U. Day, Akos A. Gerencser, Alan Hubbard, Simon Melov

Journal:

Free Radical Biology and Medicine

Year:

2011

Language:

english

File:

PDF, 1.00 MB

english, 2011

40

Cellular senescence: A link between cancer and age-related degenerative disease?

Judith Campisi, Julie K. Andersen, Pankaj Kapahi, Simon Melov

Journal:

Seminars in Cancer Biology

Year:

2011

Language:

english

File:

PDF, 280 KB

english, 2011

41

Mitochondrial DNA mutations, oxidative stress, and aging

Tamara.-R Golden, Simon Melov

Journal:

Mechanisms of Ageing and Development

Year:

2001

Language:

english

File:

PDF, 319 KB

english, 2001

42

Microarray workshop on aging

Prakash N Nair, Tamara Golden, Simon Melov

Journal:

Mechanisms of Ageing and Development

Year:

2003

Language:

english

File:

PDF, 135 KB

english, 2003

43

Insulin-like Signaling Determines Survival during Stress via Posttranscriptional Mechanisms in C. elegans

Gawain McColl, Aric N. Rogers, Silvestre Alavez, Alan E. Hubbard, Simon Melov, Christopher D. Link, Ashley I. Bush, Pankaj Kapahi, Gordon J. Lithgow

Journal:

Cell Metabolism

Year:

2010

Language:

english

File:

PDF, 2.73 MB

english, 2010

44

Life Span Extension via eIF4G Inhibition Is Mediated by Posttranscriptional Remodeling of Stress Response Gene Expression in C. elegans

Aric N. Rogers, Di Chen, Gawain McColl, Gregg Czerwieniec, Krysta Felkey, Bradford W. Gibson, Alan Hubbard, Simon Melov, Gordon J. Lithgow, Pankaj Kapahi

Journal:

Cell Metabolism

Year:

2011

Language:

english

File:

PDF, 1.62 MB

english, 2011

45

Intramyocellular Fatty-Acid Metabolism Plays a Critical Role in Mediating Responses to Dietary Restriction in Drosophila melanogaster

Subhash D. Katewa, Fabio Demontis, Marysia Kolipinski, Alan Hubbard, Matthew S. Gill, Norbert Perrimon, Simon Melov, Pankaj Kapahi

Journal:

Cell Metabolism

Year:

2012

Language:

english

File:

PDF, 550 KB

english, 2012

46

Genetic Correction of Huntington's Disease Phenotypes in Induced Pluripotent Stem Cells

Mahru C. An, Ningzhe Zhang, Gary Scott, Daniel Montoro, Tobias Wittkop, Sean Mooney, Simon Melov, Lisa M. Ellerby

Journal:

Year:

2012

Language:

english

File:

PDF, 1.81 MB

english, 2012

47

Modeling mitochondrial function in aging neurons

Journal:

Trends in Neurosciences

Year:

2004

Language:

english

File:

PDF, 324 KB

english, 2004

48

‘…and C is for Clioquinol’ – the AβCs of Alzheimer's disease

Journal:

Trends in Neurosciences

Year:

2002

Language:

english

File:

PDF, 34 KB

english, 2002

49

Mouse models of mitochondrial disease, oxidative stress, and senescence

Simon Melov, Pinar E. Coskun, Douglas C. Wallace

Journal:

Mutation Research/DNA Repair

Year:

1999

Language:

english

File:

PDF, 878 KB

english, 1999

50

Animal models of oxidative stress, aging, and therapeutic antioxidant interventions

Journal:

The International Journal of Biochemistry & Cell Biology

Year:

2002

Language:

english

File:

PDF, 55 KB

english, 2002